Application of Boron-Doped Single-Crystal Diamond in Biosensors

Boron doping endows diamond with more excellent properties and expands the application fields of diamond films. In particular, boron-doped diamond films exhibit significant performance advantages in electrochemistry. On the basis of overcoming technical challenges such as improving charge storage capacity and bioactive unit immobilization, and solving key issues including enhancing manufacturing efficiency and controlling costs, the applications of boron-doped diamond films will surely be further expanded, presenting broad prospects.

Since the main element of diamond is carbon, which possesses excellent biocompatibility, boron-doped diamond electrodes are expected to be widely applied in biosensors. Although there are currently no practical large-scale application cases of boron-doped diamond electrodes in the field of biosensors, researchers at home and abroad have carried out extensive studies on the modification of boron-doped diamond electrodes, the immobilization of biological components, and the development of biosensors for multiple purposes.

The excellent chemical and electrochemical properties as well as good biocompatibility of BDD electrodes make them widely applicable in the field of bioelectroanalysis. Using pristine or simply treated BDD film electrodes, selective determination of specific substances in complex biological systems can be achieved. Surface modification of BDD electrodes to immobilize specific bioactive units transforms them into biosensing elements. Different surface modifications and immobilization of different bioactive units on BDD electrodes correspond to a wide range of detection applications.

At present, studies on boron-doped diamond electrodes in the fields of glucose, dopamine, NADH, ascorbic acid, and amperometric biosensors have been reported. The immobilization of bioactive units is also the core technology of boron-doped diamond biosensors; immobilizing different active units enables the detection of different biological substances and may even realize human implantation applications.

The boron-doped single-crystal diamond produced by CSMH can achieve doping from low concentration to high concentration. It has realized a uniform and controllable concentration and a customizable boron doping process.CSMH uses the MPCVD method to prepare large-sized and high-quality diamonds,and currently has mature products such as diamond heat sinks, diamond wafers, diamond windows,diamond hetero junction integrated composite substrates,etc